Thursday 19 May 2016

What is active site of an enzyme?

Active site-

Definition- It is a binding site in enzyme  where the substrate binds to yield enzyme substrate complex and products by enhancing the chemical reaction.

The active site is usually a groove or pocket of the enzyme which can be located in a deep tunnel within the enzyme.

The active site fits with one specific type of substrate.Residues in the binding site form hydrogen bonds ,hydrophobic interactions, or temporary covalent interactions (vanderWaals) with the substrate to make an enzyme-substrate complex. 

Active site have 2 regions with unique  activities -

1.Binding site- Where the substrate binds.
2.Catalytic site- For catalytic chemical reaction.




                                    Image source-http://analytical.wikia.com/wiki/Active_site?file=Active_site.gif


Catalytic site
Where reaction
occurs
Binding
Site
holds
substrate
in
place Substrate
Enzyme
THE ACTIVE SITE

                              Image source-http://www.slideshare.net/AneettaDavis/simple-eutectic-systempb-ag




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