BRIEF INTRODUCTION ABOUT VDJ RECOMBINATION

V-VARIABLE SEGMENT
D-DIVERSITY SEGMENT
J-JOINING SEGMENT

• 1.Which of the following is only contained in heavy chains and not in light chains?

• A. 
  Leader (L)
• B. 
  Joining (J)
• C. 
  Diversity (D)
• D. 
  Variable (V)                                                 Ans. c 

• 3.During the development of B cells VDJ recombination occur the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination).

  
  

• 4.In the developing B cell, the first recombination event  occur in between one D and one J gene segment of the heavy chain locus. This D-J recombination is followed by the joining of one V gene segment, from a region upstream of the newly formed DJ complex, forming a rearranged VDJ gene segment.
  
  
  

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