COMPARISION BETWEEN MHC-I AND MHC-II PROTEINS

1.The MHC class I heavy chain consists of:

 A  Beta2-microglobulin.
 B  Three Ig-type domains.
C Three globular domains.
D Two globular domains.

Ans. C They consist of one membrane-proximal immunoglobulin-type domain and two membrane-distal domains which form a grooved structure comprising two extended alpha-helices lying on top of a beta-pleated sheet floor which can bind peptides generated by cytoplasmic protein processing.

2.The MHC class II beta chain has a molecular weight of:

 A  28–29 kDa
 B  34 kDa
 C  43–44 kDa
D  11–12 kDa

Ans. A Like the alpha chain, the beta chain is a transmembrane glycoprotein with two extracellular globular domains.

3.Extensive allelic polymorphism is found in MHC:

 A  DRbeta.
 B  DRalpha.
 C  beta2-microglobulin.
 D  Class I alpha3 domain.

Ans. A  Class I HLA-A, -B and -C molecules are highly polymorphic, so are the class II molecule DRbeta, DPbeta and DQbeta chains,

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