CDR OR HV AND FRAMEWORK REGION

Variable Ig domain has anti-parallel beta-pleated sheet structures.

  It uses beta-turn loops to bind antigen.It has an extra long beta-turn relative to constant region domains. It has a typical Ig fold with an intra-chain disulfide bond.

1.The complementarity determining regions:

 A  Are restricted to light chains.
 B  Are in the constant part of the Ig molecule.
 C  Bind to Fc receptors.
D  Are concerned in antigen recognition.

Ans. D  3 CDR's in the heavy and 3 in the light chain may all be concerned in forming the antigen recognition structure.

2.In the preparation of humanized antibody, part of the antibody molecule is taken from mouse and the remaining is taken from that of human, through genetic engineering technique. Which one of the following statements is true for humanized antibody?

(A) CDRs of mouse IgG is fused with framework regions of human IgG
(B) CDRs of human IgG is fused with framework regions of mouse IgG
(C) CDRs of mouse IgG is fused with CDRs of human IgG
(D) framework regions of mouse IgG is fused with framework regions of
human IgG
And. A

Thank you for visiting my video tutorial/blog.Please feel free to share your comment on this

article ,Please subscribe and share the articles to get more such articles.