TOLL - LIKE RECEPTORS

1.What is the name for the cytoplasmic domain of a TLR receptor?

Ans. Toll-IL1-R, or TIR domain

2.The TLR9 pattern recognition receptor recognises:

 A  CpG motifs.
 B  Gram +ve peptidoglycan.
 C  Mycobacterial lipoarabinomannan.
 D  Gram –ve LPS.  

Correct.answer -A Toll-like receptor 9 recognition of these microbial dinucleotide sequences leads to activation of the NFkB transcription factor.

3.Toll-like receptor 4 is associated with responsiveness to LPS, an endotoxin that causes lethal endotoxic shock. The mice deficient In Toll-like receptor 4 and BALB/c mice were injected with Escherichia coli. In addition, some BALB/b mice were also injected with the same bacteria alone

or with anti-interleukin-10 (IL-10) antibody. The mice resistant to the lethal effect of the bacteria were:

1. BALB/b mice receiving the bacteria.

2. BALB/b mice receiving the bacteria and the anti-IL-10 antibody

3. Mice deficient In Toll-like receptor

4. BALB/c mice receiving the bacteria.

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