T-CELL RECEPTOR

1.Th2 response is generated and maintained mainly by which of the following pair of cytokines -
A. IL-4 and IL-10
B.IFN-y and TNF-alpha
C. IL-12and  IFN-y
D. IL-2 and IL-12
Ans. A

2.T cell surface receptors for antigen partly recognize:

 A  Cytokines
 B  MHC
 C  ADCC
 D  Antibody

Ans. B  T-cells recognize processed antigen plus the major histocompatibility complex (MHC) molecules which act as a marker to inform the T-cell that it is in contact with another cell.

3.The T-cell receptor genes were originally identified using:

 A  A monoclonal anti-idiotype.
 B  The polymerase chain reaction.
 C  A liver DNA gene library.
D Subtractive hybridization.

Ans. D Given that the vast majority of the mRNA in B-cells encodes molecules also expressed in T-cells, subtractive hybridization was used as a step in the initial identification of the T-cell receptor. This technique removed from a T-cell polysomal mRNA preparation all of the mRNA molecules also present in B-cells, leaving a T-cell specific series of clones, some of which hybridized to DNA which was rearranged only in mature T-cells.

4.The T-cell receptor for antigen is:

 A  Derived from the immunoglobulin gene pool by alternative splicing.
 B  A tetramer.
 C  A homodimer.
 D  A heterodimer.

Ans.D There are two versions of the T-cell receptor, both of which are heterodimers consisting of an alpha chain and a beta chain, or a gamma chain and a delta chain

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