BCR (B-CELL RECEPTOR

1. IgD:

 A  Is pentameric.
 B  Is resistant to proteolytic degradation.
 C  Is present mainly as a surface receptor on B-cells.
 D  Is present with unusual frequency in myelomas.

Ans. C  Naive B-cells coexpress surface IgM and IgD of the same antigen specificity.

2.The first immunoglobulin heavy chain class to be expressed on the surface of a newly produced B-cell is:

 A  IgA
 B  IgD
 C  IgE
 D IgM

Ans. D IgM is the first immunoglobulin class to be expressed on the surface of the developing B-cells, shortly followed by IgD. Early mature B-cells co-express IgM and IgD antibodies of identical antigen specificity.

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